Physical stability in suspensions is controlled by (1) the addition Flocculation, in the field of chemistry, is a process by which colloidal particles come out of suspension to sediment under the form of floc or flake, either spontaneously or due to the addition of a clarifying agent. and r2 is the density of the medium rate in the flocculated suspension. This, in turn, assists product homogeneity and decreases aggregation. High Efficiency Flocculating Agents In Pharmaceutical Suspensions Dadmac 7398-69-8. ), and rheologic aspects. poured and spread). In an alkaline environment the particles repulse each other, this state is called "deflocculation". Buffers and pH adjusting agents They are added to stabilize the suspension to a desired pH range. thus increase the rate of sedimentation. c. Flocculating agents / suspending agents: There are usually three basic techniques used to formulate a suspension (1) controlled flocculation (2) structured flocculation and (3) combination of 1 and 2. Assuming that all dispersed It is non-ionic, so no change in pH of medium 2. Although the Stokes' equation does not consider all the variables which external phase in poises (g/cm sec). opposite that of the net zeta potential of the suspended particles. Pharmaceutical suspensions contain finely divided drug particles distributed in a liquid, often water, in which the drug exhibits a minimum solubility. Relatively strong bonding forces develop between the suspended particles, and floccules … far apart so that the movement of one does not affect the neighboring particles, Flocculating agents are either inorganic salts or water‐soluble organic polymers. can be retarded. 7. International Journal of Pharmaceutics, 9 (1981) 315-319 315 Elsevier/North-Holland Biomedical Press Effect of surfactants on the flocculation of magnesium carbonate suspensions by xanthan gum J.L. Since the particles are linked together only loosely, Packaging and storage of suspensions: All suspensions should be packaged in wide mouth container having adequate airspace above the liquid … Flocculating agents They are added to floc the drug particles Thickeners They are added to increase the viscosity of suspension. viscosity-imparting agent and a flocculating agent, which, when used at appropriate concentrations, allow the optimum rate of sedimentation and easy redispersion in a quality product. These are briefly summarized below. This leads to a greater flexibility in the use of additives such as preservatives, flavoring and coloring agents that might be needed affect the stability of a suspension, it gives an approximation of the Now we need some means to reduce Normally, in an acid environment, the particles of an argillaceous material are attracted to each other, this state is called "flocculation". reducing the movement (sedimentation) of suspended particles and physically This is particularly important in flocculated Finally, drugs in suspension are chemically more stable than in solution. In this study the combination of the suspending agents showed better results in comparison with other formulations. Pharmaceutical suspensions are discussed with regard to theoretical ­considerations (e.g., interfacial properties, electric double layer, wetting, flocculated and deflocculated systems), stability factors (e.g., settling and sedimentation, effect of particle size, crystal growth, and use of structured vehicles, etc. How to use suspending agent in a sentence. Examples of flocculating agents are: Practically speaking, the viscosity of the dispersion Background: Nitrofurantoin is a nitrofuran antibiotic that has been used for treatment of urinary tract against positive and negative bacteria. As such, polymers can have an advantage over ionic flocculating agents in that they are less sensitive to added electrolytes. medium is the only other Stoke's variable affecting sedimentation rate Suspensions of insoluble drugs may also be used externally, often as protective agents. In order to attain appropriate flocculating, agents such as inorganic salt, organic polyelectrolyte, and mineral hydrocolloid are added in the form of natural or synthetic polyelectrolytes of high molecular weight, which interconnect and enmesh the colloidal particles into giant flocks, 10 mm in size, that are used in flocculations. Pharmaceutical Suspension can improve chemical stability of certain drug. They are easy to use, have relatively high patient acceptability, and are particularly useful for the delivery of drugs that are chemically unstable in solution, but stable in suspension. Ideally, the system should (rheologically) be pseudoplastic; of floccules or clusters as particles are held loosely together by weak it begins to settle. For example, by reducing the particle size or by increasing the Surface-active agents may influence the stability of pharmaceutical suspensions in several ways. E.g.Procaine ... Flocculating Agents Flocculating agents decreases zeta potential of … The most common categories of flocculating … Flocculating agents: Simple neutral electrolytes in solution that are capable of reducing the zeta potential of suspended charged particles to zero are considered to be primary flocculating agents. the surface charge on the suspended particles and allows the formation and (2) the addition of viscosity enhancers to reduce sedimentation PHARMACEUTICAL SUSPENSIONS: PATIENT COMPLIANCE ORAL DOSAGE FORMS *R. Santosh Kumar and T. Naga Satya Yagnesh GITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam, A.P-530045. Orally administered suspensions, containing a wide class of active ingredients (e.g., antibiotics, antacids, radiopaque agents) are of major commercial importance. Flocculants, or flocculating agents (also known as flocking agents), are chemicals that promote flocculation by causing colloids and other suspended particles in liquids to aggregate, forming a floc. The concentration used is less than 0.5 %. agents are added to suspensions to thicken the suspending medium, thereby The surface area is reduced by particle agglomeration to either form aggregates (if a flocculating agent is not added) or floccules (if flocculating agent is added) Formulation of suspensions - Deflocculated type using a suspending agent to maintain deflocculated particles in suspension. Suspending agent excipients help active pharmaceutical ingredients stay suspended in the formulation and prevent caking at the bottom of the container. Simple neutral electrolytes in solution that are capable of reducing the zeta potential of suspended charged particles to zero are considered to be primary flocculating agents. In the … Caking. addition of the flocculating agent, at some critical concentration, negates Osmotic agents They are added to adjust osmotic pressure comparable to biological fluid. Suspending agent definition is - a substance (such as carrageenan, xanthan gum, or cellulose ether) that is added to fluids to promote particle suspension or dispersion and reduce sedimentation. • Wetting Agents Non-ionic surfactants are most commonly used as wetting agents in pharmaceutical suspension. Flocculating agents are electrolytes which carry an electrical charge FVu/Vo. Flocculating agents decreases zeta potential of the suspended charged particle and thus cause aggregation (floc formation) of the particles. systems in which rapid particle settling is the primary factor leading of flocculating agents to enhance particle "dispersability" Controlled flocculation can be achieved by a combination of control of particle size and the use of flocculating agents. NaCl 0.02% as flocculating agent in presence of PVP improved the rheological behavior of suspension. They act by shrinking the ionic double layer, or neutralizing the surface charge of suspended particles, or bridging between particles. Zatz, P. Sarpotdar, G. Gergich and A. Wong Rutgers College of Pharmacy, P.O. process. - KCl / NaCl the rate of sedimentation can be estimated by Stoke's equation: where V is the sedimentation rate (cm/sec), d the diameter of the suspended Flocculants are used in water treatment processes to improve the … 2016, ABSTRACT A pharmaceutical suspension is a coarse dispersion of insoluble solid (g/cm3), g is the acceleration of gravity (980.7 cm/sec2) The components of each category are individually selected for their use in the preparation of orally, topically, or parenterally administered suspensions. Types of flocculating agents – Electrolytes: alter the electrical barrier between particles and allow the flocs to form e.g. Caking. particles are of uniform shape and size and that the particles are sufficiently Flocculation in the sulfamerazine suspension system is principally due to the chemical reaction that takes place between dioctyl sodium sulfosuccinate anions and the trivalent cations of the flocculating agent. as well as pseudoplastic are desirable, since they recover slowly from the deformation that occurs through shearing (i.e. The addition of the flocculating agent, at some critical concentration, negates the surface charge on the suspended particles and allows the formation of floccules or clusters as particles are held loosely together by weak van der Waals forces. Coloring agents They are added to impart desired color to suspension … Examples of flocculating agents are: • Neutral electrolytes such as KCl, NaCl. In suspensions, a liquid and an insoluble solid meet to form an interface. that is, it should have high viscosity at low shear rates (during storage) Effect on wetting Surface-active agents decrease the contact angle of insoluble particles, enabling greater wetting by the vehicle. may be controlled by pharmaceutical manipulation. Small conc. Suspending agents which are thixotropic and ho is the viscosity of the Settling or sedimentation is pro… of preventing caking, then we will increase the particle diameter, and upon shaking, they remain fluid long enough to be • Polysorbate 80 (Span 80) is the most widely used for parenteral and oral preparations for the following reasons: 1. this rate of settling, so that the suspension can be accurately dosed before Flocculation modifiers: These are neutral electrolytes that are capable of preventing caking of suspended solids. Flocculating agents are electrolytes which carry an electrical charge opposite that of the net zeta potential of the suspended particles. The action differs from precipitation in that, prior to flocculation, colloids are merely suspended, under the form of a stable dispersion, in a liquid and are not truly dissolved in solution. Addition of both a structured vehicle & a flocculating agent (Ideal Flocculated suspension product) Ratio of the equilibrium volume of the sediment (Vu) to the total volume of the suspension (Vo) is known as the sedimentation volume (F). Flocculating Agents flocculating agents decreases zeta potential of the suspended charged particle and thus cause aggregation (flock formation) of the particles. Add the vehicle containing the suspending agent or flocculating agent 5. The Pharmaceutics and Compounding Laboratory. Article Received on 19 October. to physical instability and lack of dosage uniformity in the product. However, it is difficult and also impractical to impose a sharp boundary between the suspensions and the dispersions having finer particles. The particles of an argillaceous material, when suspended in water, behave in two entirely different ways, since the electrostatic charges present on their surface may cause both attraction and repulsion. they will not cake and may be easily redispersed by shaking the suspension. settling rate and an appreciation of the variables governing the sedimentation viscosity and density of the external phase, the rate of sedimentation Rheological studies showed pseudoplastic behavior for all suspensions prepared by combination of the suspending agents. The rate of sedimentation of a suspended phase depends on several factors which and low viscosity at high shear rates (during shaking, pouring, or spreading). The van der Waals forces. Make up the dispersion to the final volume. Flocculating agent changes zeta-potential of the particles (it can be electrolyte, charged surfactant or charged polymer adsorbing on a surface). Suspended particles should also be small and uniform in size to provide a smooth and elegant product that is … • Sulfate, citrates, phosphates salts If the absolute value of the zeta-potential is too high the system deflocculates because of increased repulsion and the dispersion cakes. The formulation of a pharmaceutical suspension requires careful consideration of how to ensure homogeneous drug distribution during administration. In addition, disagreeable tastes can be masked by a suspension of the drug or a derivative of the drug, an example of the latter being the drug chloramphenicol palmitate. Flocculating agents decreases zeta potential of the suspended charged particle and thus cause aggregation (floc formation) of the particles. stabilizing the product. A pharmaceutical suspension is a coarse dispersion of insoluble solid particles in a liquid medium. Objectives: The aim of this study was to evaluate the effect of structural vehicles and flocculating agents on physical stability and rheological behavior of nitrofurantoin suspension. boundary is seen when the particles settle. Floccules have approximately the same size particles; therefore a clear Formulation of Suspensions Biphasic liquids such as suspensions and emulsions are unique dosage forms because many of their properties are due to the presence of a boundary region between two phases. particles (cm), r1 its density ....) is a specialized manufacturer and supplier of water treatment chemicals, pulp/paper chemicals and textile auxiliary agents in China, with decades of experience in R&D, production and application service. Abstract. As we can see from Stoke's Law, if we apply flocculation as a means Box 789, Piscatawqy, NJ 08854 (U.S.A.) (Received February 23rd, 1981 (Revised version July 21 st, … 2.2.2 Flocculating Agents. Preservatives to control microbial growth: Compatibility with diluents and other injectable p... Test methods for pharmaceutical suspensions: Processing of preparing injectable suspensions. Examples of flocculating agents used in pharmaceutical suspension (usually at concentrations 0.01 – 1.00 %) include sodium or potassium chloride, aluminum chloride, calcium salts, … over which the pharmacist can exert any control. The type of flocculant used depends on … One of the properties of a well-formulated suspension is that it can be easily re-suspended by the use of moderate agitation or shaking. Polymers can play an important role as flocculating agents in pharmaceutical suspensions. Suspending or thickening Non-caking. 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